Deep morphea belongs to a group of diseases called scleroderma. Scleroderma is a chronic disease that involves the microvasculature and connective tissue and results in fibrosis. Two different clinical categories are generally identified: systemic sclerosis, in which visceral changes are present, and localized scleroderma (morphea), in which lesions are limited to the skin Generalized morphea and deep morphea are characterized by sclerosis in the septal portions of the subcutaneous fatty tissue and the deeper layers of the dermis (Fig. 1A, 1B).After the inflammatory phase, extensive sclerosis and hyalinization extend into the underlying fascia Morphea is a rare skin condition characterized by small red or purple patches that develop firm white or ivory centers. The affected skin becomes tight and less flexible. Morphea (mor-FEE-uh) is a rare condition that causes painless, discolored patches on your skin. Typically, the skin changes appear on the belly, chest or back
. Any subtype of morphoea can affect connective tissue under the skin, such as the fat, fascia, muscle, bone, joints, or rarely brain (in craniofacial linear morphoea). Deep tissue involvement is a marker of severe disease. When the fascia (the connective tissue under the fat layer) is involved Morphea is a fibrosing skin disease with a spectrum of presentations ranging from localized indurated plaques to circumferential involvement of limbs that impairs mobility.1 Eosinophilic fasciitis (EF) is often considered a severe form of morphea.1 Treatment of severe sclerosing diseases, such as generalized deep morphea (GDM) and EF, can be challenging
Deep circumscribed morphea extends into the subcutaneous tissues. Generalized Morphea. Generalized morphea is seen when there are many patches of morphea (greater than four plaques in many anatomical areas (trunk, arms, head or neck). They are seen as thick, tight patches that can blend into each other. Pansclerotic morphea is a severe form of. Morphea, also known as localized scleroderma, is an uncommon fibrosing condition of the skin and underlying tissue. Although the etiology is unknown, morphea is considered an autoimmune condition in which genetic and environmental factors contribute to disease onset.1 Although most cases are spontaneous, several inciting factors are associated with morphea, including trauma, surgery. Deep morphea (morphea profunda) is characterized by plaques that are diffuse, mildly inflamed, hyperpigmented, symmetrical, and somewhat ill defined. 1 The skin feels thickened, taut, and bound down to the underlying fascia and muscle. 1,6,7 Plaques are smooth and shiny, but areas of both dermal and subcutaneous atrophy may be present.
The deep morphea is a type of scleroderma that causes damage to the dermis, the adipose tissue, the muscle and the underlying bone. References Deep Morphea Bielsa I, Ariza A.Seminars in Cutaneous Medicine and Surgery, 2007 Jun;26(2):90-5. Deep morphea belongs to a group of diseases called scleroderma. Scleroderma is a chronic disease that. Deep morphea encompasses a variety of clinical entities in which inflammation and sclerosis are found in the deep dermis, panniculus, fascia, or superficial muscle. Morphea profunda, eosinophilic fasciitis, and disabling pansclerotic morphea of children are included in this group, but overlapping of the extent and depth of cutaneous involvement. Morphea is a skin condition that causes patches of reddish skin that thicken into firm, oval-shaped areas.It is a form of scleroderma.. Patches most often occur on the abdomen, stomach, and back, and sometimes on the face, arms and legs. Morphea is classified according to the localization of the lesions and the depth of tissue involvement into localized or circumscribed (limited to one or. Deep morphea is a form of localized scleroderma in which inflammation and sclerosis are found in the deep dermis, panniculus, fascia, or superficial muscle, typically in the face, trunk and limbs . Associated clinical findings, including arthralgias
Morphea, also known as localized scleroderma, is a disorder characterized by excessive collagen deposition leading to thickening of the dermis, subcutaneous tissues, or both. Morphea is classified into circumscribed, generalized, linear, and pansclerotic subtypes according to the clinical presentation and depth of tissue involvement We describe two young children who had morphea consistent with the deep morphea type (morphea profunda) that appeared at the site of a previous vaccination. Trauma has been implicated as an important trigger of morphea, both in children and in adults. Furthermore, vaccines might induce an immune response, which could lead to morphea in.
Diagnosis. Your doctor may diagnose morphea by examining the affected skin and asking about your signs and symptoms. Your doctor might also take a small sample of your skin (skin biopsy) for examination in a laboratory. This can reveal changes in your skin, such as thickening of a protein (collagen) in the second layer of skin (dermis)
Morphea profunda involves deep subcutaneous tissue, including fascia, and there is a clinical overlap with eosinophilic fasciitis, eosinophilia-myalgia syndrome, and the Spanish toxic oil syndrome.: 171 Morphea profunda shows little response to corticosteroids and tends to run a more chronic debilitating course Treating morphea at an early stage may require potent drugs or aggressive localized therapy to prevent spreading and progression, hence physicians should refrain from using topical steroids as a first-line therapeutic agent in cases of extensive, deep, or rapidly progressive morphea Although eosinophilic fasciitis is known to be part of the deep morphea spectrum, this first report of the coexistence of granulomatous fasciitis and morphea profunda suggests that granulomatous fasciitis may also be a part of the spectrum of deep morphea Improvement in musculoskeletal involvement has also been observed in a prospective study of adults with deep morphea (mean age 52 years) . When added to MTX and prednisone, imatinib, which inhibits fibroblast activity, halted the progression of skin disease and joint deformity in a 3-year-old patient
[Deep morphea-type lesions, first manifestations of lymphocytic lymphoma]. [Article in French] Plantin P(1), Le Leannec N, Delmas A, Le Berre A, Leroy JP. Author information: (1)Service de Dermatologie, Hôpital Laennec, Quimper Deep morphea syndromes are characterised by the involvement of the deep dermis, subcutaneous tissue fascia or superficial muscle.  Eosinophilic fasciitis is a distinct syndrome described by Shulman, consisting of sclerotic fasciitis, peripheral eosinophilia, elevated ESR and hypergammaglobulinemia
The morphea profunda diagnosis was made by biopsy in my lower left arm, since I was having joint contractures in my left hand, and also had linear and plaque morphea on my left lower arm. But I had the morphea on my back and under my breast for probably two years prior to that, and just thought it was a sunburn that was taking a long time to. Diagnosis. Your doctor may diagnose morphea by examining the affected skin and asking about your signs and symptoms. Your doctor might also take a small sample of your skin (skin biopsy) for examination in a laboratory. This can reveal changes in your skin, such as thickening of a protein (collagen) in the second layer of skin (dermis)
Background Deep Variant Morphea (DMV), previously known as morphea profunda, is an exceptionally rare form of sclerosis that is confined to the skin, and unlike scleroderma, has no systemic or internal organ involvement. The inflammation and sclerosis involves layers of the deep dermis, panniculus, fascia or even the underlying superficial muscle Therapeutic Challenge. The treatment of generalized deep morphea is challenging, and no single therapy has proven to be very effective or significantly disease modifying. 1,2 Numerous treatments, some with potentially hazardous adverse effects, are currently used with only limited success. 3 Topical and intralesional corticosteroids may be useful for discrete lesions, and newer topical agents. Morphea, also referred to as LS, is a fibrotic autoimmune disease of the skin and underlying tissues that is equally frequent in children and adults. 1, 2 The clinical subtypes (superficial circumscribed morphea, generalized morphea, deep morphea, and linear and mixed scleroderma) 3 share the same histologic features as systemic scleroderma. Deep morphea treatment Treatment and cure for guttate morphea Is sterapred used in the treatment of morphea ? Download Here Free HealthCareMagic App to Ask a Doctor. All the information, content and live chat provided on the site is intended to be for informational purposes only, and not a substitute for professional or medical advice.. Subtypes of morphea. There are several subtypes of morphea including plaque morphea, generalized morphea, deep morphea, and bullous morphea. All types of morphea change with time.Initially, there may be more and bigger patches, but those soften and darken over time, with each patch lasting about three to five years.. What does morphea look like
Deep tissue involvement in morphea Any subtype of morphea can affect connective tissue under the skin, such as the fat, fascia, muscle, bone, joints or rarely, brain (in craniofacial linear morphea). Deep tissue involvement is a marker of severe disease Morphea is an inflammatory disease of the dermis and subcutaneous tissue. The disorder is more common among women and has no age predilection. Moreover, it is characterized by asymmetric distribution of slightly elevated, erythematous or violaceous edematous plaques that undergo centrifugal expansion, with central scarring and postinflammatory pigmentation as the lesions age (Fig. 3.19) Circumscribed morphea is the most common variant and further differentiated into superficial and deep variants. In one cohort study, circumscribed morphea was responsible for 60-65% of the patients. The liner morphea includes the limb or head variant based on the location of the lesion Journal compilation u0002 2006 Blackwell Publishing, Inc. f Torrelo et al: Deep Morphea after Vaccination 485 Figure 1. Puckered skin with deep induration at the site of vaccination (Patient 1). Patient 2 A 2-year-old girl was sent for the evaluation of a deep induration of her lower left limb. She was a healthy infant, who had developed.
Morphea, also sometimes called localized scleroderma, is a rare autoimmune disorder that causes skin thickening, hardening, and color changes. It often only affects the outer layer of skin but sometimes leads to more serious issues due to the involvement of deeper parts of the body Deep morphea is a rare subtype in both the adult and pediatric populations (*5%) [1 ,9 10]. Lower extremities are often affected symmetri-cally, where sclerosis might cause contractures and lead to subcutaneous atrophy. 2.3.4 Linear Morphea In linear morphea, sclerosis may be limited to the dermis Pansclerotic morphea is a debilitating variant that affects subcutaneous tissues and even bone. There is associated muscle atrophy, joint contractures, and nonhealing ulcers. Complications include: Joint mobility and impairment of muscle growth - in linear or deep morphea crossing joint line Deep morphea is similar in that it affects deep structures such as deep dermis, subcutaneous tissue, or superficial muscle, but it presents diffusely rather than linearly . Because there is not a specific, confirmatory test, the diagnosis of morphea is made clinically and histopathologically [ 4 ]
Localized scleroderma (LS), or morphea, has been classified into plaque, generalized, linear, and deep forms 1. The natural progression of the plaque form of LS is of a gradual softening to spontaneous resolution after a mean duration of 4 years with the plaque group having the shortest period of activity and the deep form the longest 2 Deep morphea: This is the most harmful form of LS. Fortunately, it is quite rare. Deep morphea affects the tissue just below the skin, including bone and muscle. Systemic Scleroderma . Also called systemic sclerosis (SS), this type of scleroderma causes widespread thickened skin throughout the body. Widespread skin involvement may lead to. classiﬁcation of localized scleroderma, deep morphea encompasses morphea profundus, eosinophilic fasci-itis (EF), and disabling pansclerotic morphea of children (DPM) (1,2). Typically, deep morphea ex-tends from the deep dermis to muscle in a diﬀuse pattern, separating it from other forms of morphea (3) Linear morphea is characterized by unilateral, deep, band-like cutaneous sclerosis and is the most common subtype in childhood-onset morphea. 2,8 Limb-length differences and subcutaneous atrophy.
In a population-based study of LS , CM accounted for 56%, generalized morphea for 13%, linear morphea for 20%, and deep morphea for 11%. The female-to-male ratio of LS is 2.4:1, the mean age at onset is approximately 7.3 years  , and there are no differences in the various LS subtypes  Deep circumscribed morphea is characterized by fibrosis affecting the deep dermis, adipose tissue, and muscle but unlike the linear variety is not linear in the pattern but more diffuse. Generally, the morphea lesions present as well-circumscribed areas of shiny indurated skin with a violaceous border (inflammatory stage) 'deep morphea' is intended to describe the histologi-cal findings of superficial muscle, fascia, adipose tis-sue and deep dermis involvement in a clinically loca-lized way. Generalized morphea is different from SSc. Patients may develop sclerosis of the fingers, bu Morphea, also referred to as LS, is a fibrotic autoimmune disease of the skin and underlying tissues that is equally frequent in children and adults.1,2 The clinical subtypes (superficial circumscribed morphea, generalized morphea, deep morphea, and linear and mixed scleroderma)3 share the same histologic features as systemic scleroderma: deep
Y1 - 2008/1/1. N2 - OBJECTIVE. Our objective was to describe the spectrum of MRI features in patients with deep and generalized morphea. CONCLUSION. Imaging features of morphea are not specific and usually overlap with those of other disorders involving the skin, fascia, and musculature, such as some types of fasciitis, myositis, and so forth OBJECTIVE Our objective was to describe the spectrum of MRI features in patients with deep and generalized morphea. CONCLUSION Imaging features of morphea are not specific and usually overlap with those of other disorders involving the skin, fascia, and musculature, such as some types of fasciitis, myositis, and so forth. Nevertheless, the imaging features of morphea reflect pathomorphologic.
Linear and deep (panslerotic) morphea may cause considerable morbidity, especially in children, interfering with growth. Joint contractures, limb-length discrepancy, and prominent facial atrophy (shrinkage of underlying tissues) can cause substantial disability and deformity in people with linear or deep morphea. [7 • Circumscribed (plaque) morphea is the most common variant in adults, presenting with ≤3 discrete indurated plaques; the latter favor the trunk and tend to develop in areas of pressure (e.g. hips, waist, and bra line in women); superficial and deep variants (morphea profunda) exist Morphea can be divided into several clinical groups: plaque-type morphea, linear morphea, generalized morphea, deep morphea, nodular morphea, and guttate morphea. Patient with morphea does not have involvement of internal organs and Raynaud's phenomenon. Some patients may have involvement of muscles, tendons,. Deep morphea. This primarily involves the deep dermis, subcutaneous tissue, fascia, or superficial muscle. The lesions are more diffuse than in linear scleroderma and do not demonstrate a linear pattern. Subtypes include subcutaneous morphea, morphea profunda, disabling pansclerotic morphea of childhood, and eosinophilic fasciitis. Subcutaneous.
Morphea can be divided into the following clinical subtypes: linear, plaque type (including guttate and keloidal), generalized, bullous, and deep morphea. In children, morphea is observed in a 2-3:1 female-male ratio, with the mean age of onset ranging from 7-10 years Some of the most common of these include Generalized Morphea, Morphea Profunda, Deep Morphea, Guttate Morphea and Bullous Morphea. What Causes Morphea? Morphea scleroderma is catagorised the same as the more serious condition systemic scleroderma otherwise known as systemic sclerosis, both conditions are types of autoimmune disorders, that. Morphea, or localized scleroderma, usually begins between the ages of 20 to 50 years as patches of yellowish or ivory-colored rigid, dry skin (inflammatory stage). These are followed by the appearance of firm, hard, oval-shaped plaques with ivory centers that are encircled by a violet ring Symptoms of deep morphea Download Here Free HealthCareMagic App to Ask a Doctor All the information, content and live chat provided on the site is intended to be for informational purposes only, and not a substitute for professional or medical advice Lupus erythematosus panniculitis with morphea-like lesions. Stork J (1), Vosmík F. (1)2nd Department of Dermatology, Charles University, Prague, Czechoslovakia. A 22-year-old female with morphea-like lesions, deep subcutaneous nodules and lipoatrophic areas of the skin on lateral aspects of the upper arms, on the breasts and on the buttocks is.
Morphea, also known as localized scleroderma, is a rare disorder characterized by excessive collagen deposition leading to thickening of the skin, subcutaneous tissues, or both. It is classified into plaque, generalized, linear, and deep subtypes Deep morphea or morphea profunda with involvement of the subcutaneous fat may require an incisional wedge biopsy for diagnosis. The presence of eosinophils in the fascia of inci-sional biopsies may indicate overlap with eosinophilic fasciitis.20 On histopathologic examination, inﬂammatory (active Deep type: This type includes subcutaneous morphea or morphea profunda, eosinophilic fasciitis and pansclerotic morphea. As this classification was subject to controversy, Laxer and Zulian proposed a new classification in 2006 involving five types: circumscribed , linear , generalized , pansclerotic , and mixed variants of morphea Solitary morphea profunda (SMP) is a variant of localized scleroderma (LS). We report the case of a 50-year-old white woman with a history of trauma sustained in an automobile accident who presented with SMP on the right upper arm. We also provide a review of the classification, epidemiology, etiology, diagnostic studies, pathogenesis, physical findings, histopathology, treatment, and. The aim of the study is to assess the long-term safety and efficacy of hyaluronic acid (HA) administration in correction of facial morphea lesions and to review the literature on the subject. Morphea is a chronic inflammatory disease of the connective tissue which may lead to serious deformations. The lesions located on the face particularly affect patients' quality of life and self-esteem.
Morphea is a chronic inflammatory disease characterized by sclerosis of the skin. The term localized scleroderma is also used in some texts. This causes confusion with systemic sclerosis (scleroderma), often resulting in unnecessary evaluation and anxiety. It is the opinion of the authors that the term localized scleroderma should be avoided Deep Morphea after Vaccination in Two Young Children Deep Morphea after Vaccination in Two Young Children Torrelo, Antonio; Suárez, José; Colmenero, Isabel; Azorín, Daniel; Perera, Antonio; Zambrano, Antonio 2006-09-01 00:00:00 Besides the better known complications of vaccination, a number of dermatoses have been reported to appear in close temporal or spatial relationship to the. . Provoking factors contributing to the development of morphea include infection, trauma, radiation therapy, or injection. Morphea has been found to be associated with local injections of vaccination, Vitamin B12, Vitamin K1, interferon-β1a, and. (involves deep dermis, subcutaneous, fascia, muscle) Morphea profunda: involved areas have cobblestone appearance with subcutaneous atrophy. Deep Morphea(Morphea profunda) 13
Deep morphea Morphea, or localized scleroderma, is a rare fibrosing disorder of the skin resulting from inflammation and deposition of collagen-rich extracellular matrix [ 19 ]. When sclerotic changes extend beyond the dermis to involve the subcutaneous tissue, the fascia or the superficial muscle, we refer to deep variant of circumscribed. • Deep morphea . Who are at risk? Morphea affects women more than men. Age group more commonly affected is 50-70 years. Morphea is a heredity disorder. What is the pathology involved? The major cause of this condition is the overproduction and accumulation of collagen in the skin tissues En coup de sabre: This is a deep-seated form of linear scleroderma affecting the scalp and temple like from a sabre (sword). The hair is lost permanently and the underlying skull bone may shrink. Generalized morphea: This is a very rare form of morphea with widespread skin thickening over the body deep morphea - lesions more diffuse and do not demonstrate linear pattern . subcutaneous morphea . primary involvement of panniculus or subcutaneous tissue ; relatively rapid onset of sclerosis (several months) plaques hyperpigmented, symmetric, and somewhat ill-defined ; eosinophilic fasciitis . not uniformly considered on morphea spectru
Peterson et al 6 divided the morphea into five categories: plaque, generalized, bullous, linear, and deep. Plaque morphea is a superficial type of morphea that is confined frequently to the dermis and occasionally to the superficial panniculus. The various subtypes of plaque have been mentioned earlier Circumscribed morphea. Three or less separate patches localized to one part of the body. Mainly oval patches that are between 1 to 20 cm in diameter. Superficial or deep circumscribed morphea are the more common variants. Less common variants of circumscribed morphea include guttate, keloidal (nodular) and bullous morphea . The circumscribed form is most common in adults and it presents with indurated round-oval plaques. The linear form, which mostly affects children, occurs with morpheic form plaques arranged in linear distribution. En coup de sabre lesions involve morpheic lesions to the.
• Circumscribed (plaque) morphea is the most common variant in adults, presenting with ≤3 discrete indurated plaques; the latter favor the trunk and tend to develop in areas of pressure (e.g. hips, waist, and bra line in women); superficial and deep variants (morphea profunda) exist (Fig. 36.3) The term deep morphea, or morphea profunda, describes a variant of morphea (localized scleroderma) in which inflammation and sclerosis are found in the deep dermis, panniculus, fascia, or superficial muscle. Deep morphea has been recognized for many years, 1 but this form of localized scleroderma did not gain wide acceptance until the descriptions by Person and Su in 1979 and 1981. 2,3. Terri: Subcutaneous Morphea My dermatologist also said that there was nothing that could be done. I woke up one year ago today with a circular indentation in my upper arm. I was finally diagnosed with deep morphea (or subcutaneous morphea) around mid February 200, after having a biopsy Deep involvement may result in irreversible impairment secondary to pain, loss of movement and contracture. Morphea is classified into circumscribed, generalized, linear, and pansclerotic subtype according to clinical presentation and depth of tissue involvement. Collagen production is increased in all forms of morphea